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M94A0719.TXT
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1994-10-21
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Document 0719
DOCN M94A0719
TI Unravelling the molecular biology of HIV.
DT 9412
AU Rosenberg M; SmithKline Beecham Pharmaceuticals, King of Prussia, PA;
19406-0939.
SO Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:20 (abstract no.
TPI-5). Unique Identifier : AIDSLINE ASHM5/94348936
AB HIV is a genetically complex retrovirus which can integrate into the
genome of its human host and thereby remain hidden from immune
surveillance or replicate slowly to achieve its chronic infection
process. The advent of the recombinant DNA technologies have allowed
identification, molecular dissection and characterisation of many
aspects of the virus, including its structure, life cycle and
interaction with the human host. The emerging picture remains a daunting
one. The virus uses intricate mechanisms to regulate its growth, genetic
diversity and deceptive interaction and eventual destruction of the
host. Although a molecular description of HIV has certainly revealed
many vital features of the virus and has helped to identify those which
might serve as a focus of certain control strategies, the present
picture still falls short of revealing the full dimensions of the
challenge presented by AIDS.
DE Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*MICROBIOLOGY Human
HIV/*GENETICS/IMMUNOLOGY HIV Infections/IMMUNOLOGY/*MICROBIOLOGY
Molecular Biology Virus Replication/GENETICS/IMMUNOLOGY MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).